Main Outcomes and Measures Changes in areal and volumetric BMD and bone biomarkers were compared by analysis of variance, adjusted for strata. All participants were prescribed daily cholecalciferol (vitamin D) and calcium.
Interventions Placebo or low-magnitude, high-frequency mechanical stimulation (0.3 g 32-37 Hz) for 2 sessions lasting 10 minutes each, 7 days per week for 1 year. Participants were randomized (stratified by sex and Tanner stage) to either a placebo device or low-magnitude, high-frequency mechanical stimulation device, which was used at home.
Wren 1.6.10 download trial#
Objective To evaluate the ability of low-magnitude, high-frequency mechanical stimulation to enhance BMD among childhood cancer survivors.ĭesign, Setting, and Participants Double-blind randomized clinical trial conducted at St Jude Children’s Research Hospital from June 1, 2010, to January 22, 2013, using cancer survivors, ages 7 to 17 years, who were previously treated at St Jude Children’s Research Hospital, were in remission, and at least 5 years from diagnosis, with whole-body or lumbar spine BMD z scores of −1.0 or lower.
Children with cancer may develop low bone mineral density (BMD) any time before or after diagnosis. Importance Bone accrual during youth is critical to establish sufficient strength for lifelong skeletal health.
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